Description: Today’s refurbished episode features Zev Williams, M.D., Ph.D. He is the Chief of the Division of Reproductive Endocrinology and Infertility and an Associate Professor of Obstetrics and Gynecology at Columbia University Medical Center and is a nationally-recognized clinician and researcher in the area of recurrent pregnancy loss and infertility. Not only is he one of the most brilliant minds I’ve had the pleasure of interviewing, he is incredibly humble, gracious, and passionate about his work. His intentions to help couples overcome recurrent pregnancy loss by building healthy happy families came through so clearly during this chat.

We touched on why miscarriage rates are so high and why the public has false perceptions about it being a rare event. He spoke about how his research has even uncovered a way to find out if the cause of a miscarriage was chromosomal even years after the fact in some cases. He explained the differences in PGD and PGS testing when using IVF and when and for whom it might be highly beneficial. We also spoke about MTHFR gene mutation, and what it really means in regards to treatment strategy and further testing. We even touched on his work with stem cells and the potential they have for one day helping women who experience premature ovarian failure to overcome this devastating diagnosis. He explained new ways to treat endometriosis and preserve fertility and new ways to diagnose PCOS.

Takeaway:

[1:15] Dr. Williams completed his M.D. and Ph.D. training in Molecular Biology and Biochemistry at the Mount Sinai School of Medicine before continuing to the Brigham and Women’s Hospital/Massachusetts General Hospital for his residency in Obstetrics and Gynecology. After completing his fellowship in Reproductive Endocrinology and Infertility at Weill Cornell, Dr. Williams then did a post-doctoral fellowship in RNA biology in the laboratory of Dr. Thomas Tuschl at Rockefeller University.

[1:45] Dr. Williams has also achieved success in federally-funded research projects in several different areas of study, having received numerous NIH grants to support his work. Currently, as part of an NIH R01 grant, Dr. Williams is engaged with a research project intended to use placental RNA as a screening tool for diseases and complications of pregnancy, to enable early intervention, and to provide insights into disease pathogenesis for things like pre-eclampsia.

[4:35] Dr. Williams works with couples and doctors all over the world, and the research that he and his colleagues find benefits those all over looking for answers on fertility.

[5:16] The PEARL Program that Dr. Williams started stands for Program for Early and Recurrent Pregnancy Loss. It is one of the only centers in the world that is both clinically focused, and a basic/translational research program dedicated trying to understand what causes unexplained miscarriages and trying to find ways methods to prevent them in the future.

[12:22] One of the realities of human reproduction is that is a very inefficient process. Of the eggs that get fertilized, very few result in a live birth.

[19:22] Dr. Williams explains the difference between PGD and PGS testing when using IVF, and who may benefit from these tests.

[26:54] We cover the MTHFR gene mutation, and what it really means in regards to treatment, strategy, and further testing.

[32:45] Dr. Williams explains the work on helping the brain to produce its own FSH (follicle stimulating hormones) which is the bodies own version of that hormone compared to traditional injections.

[41:23] Dr. Williams shares the new ways to treat endometriosis and preserve fertility and new ways to diagnose PCOS.

[45:27] Diet is, of course, important to overall health, but also very important to pregnancy success. There are some factors that lead to Dr. Williams’ recommending a diet low in carbs and sugar.

[46:12] Egg freezing has become successful, but the challenge is that women are freezing their eggs in their 40’s when the eggs have already lowered in quality.

[49:58] Once you are trying to conceive (and of course through all of the process), make sure to support each other. It’s a tough journey and you want to be going through it together.

If you have experienced a miscarriage and are afraid of the anxiety that it may bring up with your next pregnancy I suggest you invest in a Fetal Doppler so you can check your baby’s heart rate from the comfort of your own home anytime.

Sonoline B Fetal Doppler

References:

Fertile Minds on LibSyn

Fertile Minds on iTunes

American Board of Oriental Reproductive Medicine

Dr. Zev Williams

Dr. Zev Williams Bio

Columbia University Department of Obstetrics and Gynecology

Efficient Differentiation of Steroidogenic and Germ-Like Cells from Epigenetically Related iPSCs Derived from Ovarian Granulosa Cells

FMR1 targets distinct mRNA sequence elements to regulate protein expression

Nytimes.com/2015/11/26/health/progesterone-may-not-help-women-with-history-of-miscarriages-study-finds

Huffingtonpost.com/science-of-us/miscarriage_b_8000760.html?ncid=txtlnkusaolp00000592

Wsj.com/articles/solving-the-mystery-of-miscarriages-1434389396

Columbiaobgyn.org/profile/s-zev-williams-md

Ncbi.nlm.nih.gov/pubmed/26000502

Nyp.org/enewsletters/advances/2018/gynecology/2018-Advances-Gynecology-Issue1.html

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Description:

This week’s episode is all about innovation in IVF. The highly esteemed reproductive endocrinologists, Drs. Kathy and Kevin Doody came on to talk about their process of what they call “effortless IVF” and how it helps couples conceive. The Doodys talk about their clinic in Bedford, TX, the specifics of their process, and the changes they have witnessed in over 30 years in the field of assisted reproductive medicine. In my opinion, their use of the INVOcell™ helps to make IVF as close to natural as possible. If you are someone that has hit a wall in terms of the all-natural route or is over the age of 35 and looking to check out your options, I highly recommend you have a listen.

To share your own fertility story, please email me at hillary@ladypotions.com. I look forward to connecting with you, as you are what this podcast is all about.

Takeaways:

[2:06] Dr. Kathy is board certified in Obstetrics and Gynecology and subspecialty board certified in Reproductive Endocrinology/Infertility. She has received multiple recognitions as one of Fort Worth's Top Docs, as well as one of Texas’ Super doctors. Dr. Kevin is is board certified in Obstetrics and Gynecology and sub-specialty board certified in Reproductive Endocrinology/Infertility. Dr. Kevin has received multiple honors as one of Fort Worth's Top Docs, one of Texas’ Super Doctors and one of the Best Doctors in America for the last several years. In 2017, Dr. Kevin was recognized with the Resolve National Infertility Association’s Hope Award for Achievement in recognition for his contributions. While Dr. Kevin was serving as president of the Society of Assisted Reproductive Technology (SART), he was instrumental in updating the SART National Summary Data to assist patients in making informed decisions about medical care. Dr. Kevin was also recognized as Microsoft Physician of the Year 2004. And they are married! Which is super cool.

[7:04] Their Center for Assisted Reproduction, CARE Fertility, in Bedford, Texas has an outstanding number of firsts in their location: the first ICSI pregnancy in the geographical area, they were first to successfully implement a blastocyst culture system, first in the world to use the INVOcell™ device in a blastocyst embryo transfer, and even trained the doctor in Virginia who helped the first same-sex couple both carry their baby.

[9:22] IVF, or In Vitro Fertilization, means that the egg is fertilized outside the body. ICSI, or Intracytoplasmic sperm injection, is the placement of a single sperm into the egg. It was invented in Brussels, and the Doodys were at the forefront of its discovery and implementation.

[10:36] A personal happy story! The Doodys had a hand in creating their nephew through ICSI.

[11:11] The INVOcell™ is a plastic capsule shaped like a champagne cork. It is an incubator and allows for the woman to provide the right environment and atmosphere for embryo development. It enters the uterus at the blastocyst stage.

[13:41] Dr. Kathy says it’s important for patients to understand why it makes sense to put the embryo into the body because it reflects what happens naturally in the different stages of ovulation.

[15:30] Part of the quality control is being able to make sure that the egg has normally fertilized, and it does take the place of IUI.

[17:47] The Doodys believe it is better to allow the natural competitive process when you can.

[18:20] Effortless IVF decreases the cost by about 50% and the amount of medication and monitoring that usually come with traditional IVF. The two main factors that are taken into account in a woman are her egg count, which is determined by her Anti-Müllerian Hormone (AMH) levels, and her body weight. The appropriate candidates need to have an AMH higher than 0.8, a body weight less than 190 lbs, and a BMI less than 35.

[23:40] There is a 59% success rate with frozen embryo transfers with no monitoring and transferring only one embryo in patients.

[26:41] The approach is closer to mother nature, as they are able to discern which embryo will transfer successfully.

[30:01] Dr. Kevin explains why the process is so streamlined from a laboratory standpoint, and the minimal interventions that take place in the process.

[33:21] Complex organic systems like variance and the human body is certainly an example of that.

[34:54] The INVOcell™ was founded by Dr. Claude Ranoux, a fertility specialist.

[36:47] This discovery has been a huge win for same-sex couples, as it is opening up new avenues and options for fertilization.

[41:02] Dr. Kathy’s advice for couples looking to conceive, is to realize you aren’t alone, and it is important to be proactive and seek out the options in your area. Dr. Kevin reminds us to not get discouraged, and not to let fear of failure hold you back. It is hard to give up control, and effortless IVF makes the appointments more convenient and less daunting.

References:

Fertile Minds on LibSyn

Fertile Minds on iTunes

@ladypotions4u

Center for Assisted Reproductive Care

American Society of Reproductive Medicine

Ep #30: “Male Infertility with Dr. Paul Turek”

Effortless IVF

“Comparing blastocyst quality and live birth rates of intravaginal culture using INVOcell™ to traditional in vitro incubation in a randomized open-label prospective controlled trial”

INVO Bioscience

@CareFertilityUS

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